How to Completely Disable Notification Center in Mac OS X

Follow the following steps:

 First, launch the Terminal app from /Applications/Utilities

    Enter the following command, and press Return: 

    To Disable:

launchctl unload -w /System/Library/LaunchAgents/com.apple.notificationcenterui.plist

To restore Notification Center:

    launchctl load -w /System/Library/LaunchAgents/com.apple.notificationcenterui.plist

try this at your own risk.